Split-brain Syndrome

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split-brain syndrome, also called callosal disconnection syndrome, condition characterized by a cluster of neurological abnormalities arising from the partial or complete severing or lesioning of the corpus callosum, the bundle of nerves that connects the right and left hemispheres of the brain.

Although it is not fully understood whether the processing of specific tasks is dependent on both hemispheres of the brain, the two hemispheres appear to each have some control over certain tasks. The left hemisphere, for example, is generally responsible for analytical tasks, such as calculating and reading. In many individuals, it is also the dominant centre for speech and language (though the right hemisphere is involved in language processing to a minor extent). In general, the right hemisphere is more efficient at dealing with spatial tasks, such as navigating a maze or reading a map, than the left hemisphere. The two hemispheres, however, routinely communicate with one another through the corpus callosum. This connection further serves as the conduit through which certain sensory signals are transmitted from one side of the body to the contralateral (opposite) side of the brain and through which motor control is effected in the reverse direction (i.e., the right hemisphere controls the left side of the body, and vice versa).

Among the first to characterize split-brain syndrome was American neurobiologist Roger Wolcott Sperry, who in the 1960s studied human split-brain subjects and contributed to the discovery that the left and right hemispheres of the brain carry out specialized duties. For this work, Sperry received a share of the 1981 Nobel Prize for Physiology or Medicine.